To evaluate the anti-inflammatory and analgesic activities of methanolic extract of Leaves of Adhatoda vasica Nees. (Acanthaceae) and Mentha piperita (Lamiaceae). Anti-inflammatory and analgesic activity of methanolic extract of Adhatoda\r\nvasica N and Mentha piperita L were evaluated individual & in combination. The anti-inflammatory potential of methanolic extract has been studied by using carrageenan-induced paw edema. The analgesic activity was tested by using hot plate and tail immersion method in albino rats. The phytochemical investigation was performed for the presence of vascicine, vasicinone in Adhatoda vasica N. and menthol in Mentha piperita L. The administration of methanolic extract of Adhatoda vasica Nees. and Mentha piperita at doses of 200, 400 and 600 mg/kg (p.o) significantly (P<0.01) inhibited carrageenan induced inflammation. Also treatment of extracts produced a significant (P<0.01) analgesic activity in tail immersion-induced pain and hot-plateinduced pain. Similarly, anti-inflammatory and analgesic activity were evaluated by combination of half quantity of effective doses (200+300 mg/kg) of Adhatoda vasica Nees and Mentha piperita which significantly (P<0.05) inhibit the inhibition and pain in experimental animals. The experimental results demonstrated that methanolic extract of Adhatoda vasica Nees and Mentha piperita Linn in individual and combination doses possess significant anti-inflammatory and analgesic activities
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